哈爾濱工業(yè)大學土木工程學院導師:孫艷

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哈爾濱工業(yè)大學土木工程學院導師:孫艷

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哈爾濱工業(yè)大學土木工程學院導師:孫艷 正文


  孫艷,博士,碩士生導師。1997-2005年在中國科學院大連化學物理研究所攻讀博士學位并留所工作。2005年于西班牙納瓦拉大學藥學院進行博士后研究?;貒筮M入哈爾濱工業(yè)大學,主持國家自然科學基金項目“具有“門禁”,孔道修飾和形貌可控的介孔氧化硅納米顆粒應用于siRNA靶向轉(zhuǎn)染與控制釋放的研究(3090036)”、博士點基金(20092302120070)、城市水資源與水環(huán)境國家重點實驗室開放研究基金重點項目(QAK200809),以及黑龍江省教育廳科學技術研究項目、哈爾濱市創(chuàng)新人才基金、黑龍江省新世紀高等教育教學改革工程項目和哈爾濱工業(yè)大學創(chuàng)新基金等多項科研項目,并參加國家十一五科技支撐和863等多項國家項目。并負責生物工程平臺的籌備與建設工作。目前主要從事非病毒載體、基因和藥物轉(zhuǎn)運系統(tǒng)、納米生物材料的研究,成果在Biophysical Journal 和Journal of Colloid and Interface Science等國際刊物上發(fā)表。

  專業(yè): 生物工程 聯(lián)系電話: 0451-86402695
  電子信箱: yansun@hit.edu.cn
  通訊地址:哈爾濱工業(yè)大學437信箱
  郵編:150001
  
  簡歷
  1992.9–1996.8 大連理工大學化工學院化學工程專業(yè) 獲學士學位
  1996.9–1997.7 大連理工大學信息工程學院計算機應用 獲雙學士學位
  1997.8–2004.2 中科院大連化學物理研究所生物化工 獲博士學位
  2004.3–2005.5 中科院大連化學物理研究所生物技術部 助理研究員
  2005.5–2006.6 西班牙Univeristy of Navarra大學 博士后
  2006.7-至今 哈爾濱工業(yè)大學生命科學與技術學院 副教授
  
  研究方向:
  1. 非病毒基因載體和多功能的藥物基因納米轉(zhuǎn)運系統(tǒng)
  2. 生物質(zhì)的微生物利用
  3. 生物納米材料的膠體表面化學與物理化學特性
  
  發(fā)表科研論文
  Invited Review
  1.Conchita Tros de Ilarduya*, Yan Sun, Nejat Düzgüneş. Gene delivery by lipoplexes and polyplexes (review). European Journal of Pharmaceutical Sciences, 2010, 40(3): 159-170
  2.Yan Sun. Rheological approach to targeting phenomena of lipoplexes (review). Current Drug Discovery Technologies, 2011, 8(4): 340-356
  
  Publications
  1.Yan Sun, Qi Hu, Xuetuo Li. The current situation and the development prospect of the urban environmental protection techniques in our country. Journal of Dalian University of Technology (Social Sciences), 2000, 21(s1): 48-51
  2.Yan Sun, Xuetuo Li, Sulan Yin. Effect of intestinal microecological environment on internal metabolism of traditional Chinese herbs. Zhongcaoyao (Chinese Traditional and Herbal Drugs), 2001, 32(4): 375-377
  3.Yan Sun, Xuetuo Li, Nejat Düzgüneş, Yasuyuki Takaoka, Sho-ichi Ohi, Sadao Hirota*. The shape parameter of liposomes and DNA-lipid complexes determined by viscometry utilizing small sample volumes. Biophysical Journal 2003; 85(2): 1223-1232
  4.Yan Sun*, Xingju Yu, Yasuyuki Takaoka, Sho-ichi Ohi, Nejat Düzgüneş, Sadao Hirota. Comparison of shape of DNA-cationic lipid complexes and model polyelectrolyte-lipid complexes. Journal of Colloid and Interface Science, 2004; 276(2): 317-322
  5.Yan Sun, Bo Liu, JingMei Zhao, HaiYan Wang, SuLan Yin, XueTuo Li. Effect of preparation of spirulina on intestinal flora of diabetic. Journal of Shenyang Pharmaceutical University (Chinese), 2003, 20 (4): 299-301
  6.Yan Sun, Bo Liu, Jingmei Zhao, Haiyan Wang, Heli Xu, Xuetuo Li. Comparison of intestinal flora of diabetic and health adult in Dalian. World Chinese Journal of Digestology (Chinese), 2003; 11(6): 863-865
  7.Yan Sun, Xuetuo Li, Xingju Yu. Determination of Sennoside (A+B) and Degraded products in the Process of Sennoside Metabolism by HPLC. Chromatogram (Chinese), 2004, 22 (1): 48-50
  8.Bo Liu, Yan Sun, Yonghong Li, Zongbao Zhao. Progress on microbial glyceride biosynthesis and metabolic regulation in oleaginous microorganisms. Acta Microbiologica Sinica (Chinese), 2005, 45(1): 153-156
  9.Yan Sun*, Lei Fu, Zhiqiang Xu, chongfei Xu, Qian Yang. Effect of Molecular Weight and Charge Ratio on the Stability of the Chitosan/DNA Complexes. Journal of biotechnology, 2008, 136S: S178
  10.Yan Sun, Itziar Miguéliz, Gemma Navarro, Conchita Tros de Ilarduya. Structural and Morphological Studies of Cationic Liposomes-DNA Complexes. Letters in Drug Design & Discovery, 2009, 6(1): 33-37
  11. Xianbin Liu, Yan Sun, Xiaojun Sun. “Synthesis of micron monodisperse mesoporous silica MCM-41 with shphrical porphology and applications”. Appl. No. CN 200910073248.X. 2009.11.23 (Chinese)
  12.Shiyang Tang, Xiaojun Sun, Li Lin, Yan Sun*, Xianbin Liu. Monodisperse mesoporous silica nanoparticles: synthesis and application in biomaterials. Progress in Chemistry (Chinese), 2011, 23(9), 1973-1984
  
  International Conference
  1.Yan Sun, Nejat Duzgunes, Sadao Hirota. Viscometry for determining shape parameter of DNA-lipid complex. 2nd International Congress on Drug Absorption Transport and Delivery. Poster, Hawaii, the United States, January 2003.
  2.Yan Sun, Nejat Duzgunes, Yasuyuki Takaoka, Sho-ichi Ohi, Sadao Hirota. Viscometry for determining shape parameter of non-viral vectors. 3rd International symposium on gene delivery. Poster, Tokyo, Japan, May 2003, University of Tokyo.
  3.Yan Sun*, Conchita Tros de Ilarduya. Characterizations of Plain Lipoplexes and Transferrin Lipoplexes as nanoparticles vectors for gene transfer. 13th International Biotechnology Symposium & Exhibition, October 2008, Dalian, China
  4. Yan Sun *, Lei Fu, Lang Yuan, Chongfei Xu, Conchita Tros De Ilarduya. Preparation and Characterizations of Nanoparticles Vectors for Gene Transfer. The 26th annual convention of Chinese chemical society, July 2008, Tianjin, China
  5. Yan Sun *, Chao Yang, Min Zheng, Qian Yang. Study of mesoporous silica nanoparticles on small DNA adsorption and release. 7th international symposium on biological control and bio-technology, Weihai, China, September 2009.
  6.Zhiqiang Xu, Yan Sun *, Qian Yang. Optimization of fermentation medium constituents for the activity of CMCase using response surface methodology. 7th international symposium on biological control and bio-technology, Weihai, China, September 2009.
  7.Xianbin Liu, Yan Sun *, Chao Yang, Jian Ma, Chunhui Shi, Qian Yang. Adsorptive removal of sulfanilamide, sulphamethazine and roxithromycin by mesoporous carbon. 7th international symposium on biological control and bio-technology, Weihai, China, September 2009.
  8. Li Lin, Yan Sun *. The Cell Uptake of Mesoporous Silica Nanoparticles Carrying DNA in Vitro. 9th international symposium on biological control and bio-technology, Haikou, China, December 2011.
  9.Tingsheng Yan, Yan Sun *. The Adsorption and Release of DNA by Mesoporous Silica Materials with Different Pore Diameters. 9th international symposium on biological control and bio-technology, Haikou, China, December 2011.
  
  科研項目
  主持項目
  1.國家自然科學基金青年項目(3090036):“具有“門禁”,孔道修飾和形貌可控的介孔氧化硅納米顆粒應用于siRNA靶向轉(zhuǎn)染與控制釋放的研究”
  2.教育部博士點基金(20092302120070):應用介孔氧化硅納米顆粒介導siRNA靶向轉(zhuǎn)染與控制釋放
  3.城市水資源與水環(huán)境國家重點實驗室開放研究基金重點項目(QAK200809):介孔納米材料對微污染水體中抗生素的吸附研究
  4.黑龍江省教育廳科學技術研究項目:新型基因載體介孔氧化硅材料的研究
  5.哈爾濱市創(chuàng)新人才基金(2007RFLXS012):抗腫瘤基因轉(zhuǎn)運納米載體的合成表征及機制研究
  6.哈爾濱工業(yè)大學科研創(chuàng)新基金:配體修飾的納米載體/基因復合物的形態(tài)學和轉(zhuǎn)基因研究

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