中國科學(xué)院大學(xué)研究生導(dǎo)師戴建武簡介
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中國科學(xué)院大學(xué)研究生導(dǎo)師戴建武簡介 正文
戴建武 男 博導(dǎo) 遺傳與發(fā)育生物學(xué)研究所實驗室主頁:http://dailab.genetics.ac.cn
電子郵件:jwdai@genetics.ac.cn
通信地址:北京市海淀區(qū)中關(guān)村南一條三號 中科院遺傳發(fā)育所103室
郵政編碼:100190
研究領(lǐng)域
主要研究方向:
1.生物材料與組織再生
2.干細胞自我更新與定向分化
3.干細胞微環(huán)境重建與組織工程
教育背景
1998-09--2000-05 美國哈佛大學(xué)醫(yī)學(xué)院 博士后
1996-09--1998-09 美國杜克大學(xué) 博士
1988-09--1991-07 北京醫(yī)科大學(xué) 碩士
1984-09--1988-07 武漢大學(xué) 學(xué)士
工作簡歷
2003-08--今 中國科學(xué)院遺傳與發(fā)育生物學(xué)研究所 研究員
1993-09--1996-08 美國杜克大學(xué) 訪問學(xué)者
1991-09--1993-07 北京醫(yī)科大學(xué) 任教
獎勵信息
(1) CCTV年度科技創(chuàng)新人物,其他級,2014
(2) 國家科技進步二等獎,二等獎,國家級,2012
(3) 遺傳發(fā)育所益海嘉里優(yōu)秀導(dǎo)師獎,其他級,2010
專利成果
(1) 一種脫鈣骨支架材料及其制備方法,發(fā)明,2008,第2作者,專利號:ZL 200610080609.X
(2) 與膠原特異結(jié)合的神經(jīng)生長因子及其編碼基因與應(yīng)用,發(fā)明,2008,第3作者,專利號:ZL 200610081506.5
(3) 一種膠原蛋白膜及其制備方法,發(fā)明,2007,第1作者,專利號:ZL 200410096629.7
(4) 活化的膠原骨修復(fù)材料及其專用融合活性骨修復(fù)因子,發(fā)明,2007,第2作者,專利號:ZL 200510132791.4
(5) 用于捕捉干細胞的生物材料及其制備方法與應(yīng)用,發(fā)明,2014,第5作者,專利號:ZL 201110026096.5
(6) 一種融合蛋白TAT‐NANOG及其編碼基因與應(yīng)用,發(fā)明,2013,第1作者,專利號:ZL 201110084055.1
(7) Activated Collagen Scaffold Materials and Their Special Fused Active Restoration Factors,發(fā)明,2011,第1作者,專利號:EP 1970382 B1 (歐洲)
(8) 一種表達人骨形態(tài)發(fā)生蛋白的方法及其專用表達載體,發(fā)明,2008,第4作者,專利號:ZL 200410096493.X
(9) 一個人源的Nanog基因及其編碼蛋白與應(yīng)用,發(fā)明,2008,第3作者,專利號:ZL 200510098452.9
(10) 一種生物修復(fù)材料及其制備方法與應(yīng)用,發(fā)明,2007,第3作者,專利號:ZL 200510098731.5
(11) 活化膠原蛋白支架材料及其專用融合活性修復(fù)因子,發(fā)明,2007,第2作者,專利號:ZL 200510132792.9
(12) 修復(fù)脊髓損傷的生物材料及其制備方法與應(yīng)用,發(fā)明,2013,第4作者,專利號:ZL 201010528622.3
(13) 一種融合蛋白TAT‐OCT4及其編碼基因與應(yīng)用,發(fā)明,2014,第1作者,專利號:ZL 201110084049.6
(14) 與膠原蛋白特異結(jié)合的血管內(nèi)皮生長因子及其應(yīng)用,發(fā)明,2012,第1作者,專利號:ZL 200810222219.0
(15) 一種骨支架材料及其制備方法與應(yīng)用,發(fā)明,2012,第3作者,專利號:ZL 200810056972.7
(16) 與層粘連蛋白結(jié)合的神經(jīng)生長因子及其編碼基因與應(yīng)用,發(fā)明,2013,第4作者,專利號:ZL 200910089716.2
(17) Reprogramming cells by three-dimensional cultivation.,發(fā)明,2012,第5作者,專利號:PCT/CN2012/072284
(18) 肝素、膠原材料和生長因子的交聯(lián)物及其制備方法,發(fā)明,2013,第4作者,專利號:ZL 200910089730.2
(19) 膠原材料與生長因子的交聯(lián)物及其制備方法,發(fā)明,2013,第4作者,專利號:ZL 200910089728.5
(20) 一種與纖維蛋白特異結(jié)合的重組蛋白及其應(yīng)用,發(fā)明,2013,第1作者,專利號:ZL 201110322657.6
(21) 一種用成纖維細胞制備神經(jīng)干細胞的方法,發(fā)明,2012,第5作者,專利號:201210552280.8
(22) miR-7及其應(yīng)用,發(fā)明,2013,第5作者,專利號:201310311571.2
(23) 一種誘導(dǎo)成熟細胞去分化的方法.,發(fā)明,2014,第5作者,專利號:ZL 201310017486.5
(24) OCT4B蛋白異構(gòu)體的用途,發(fā)明,2014,第5作者,專利號:ZL 201210001826.0
(25) Activated collagen scaffold materials and their special fused active restoration factors.,發(fā)明,2014,第1作者,專利號:US 8,802,396 B2 (美國)
(26) 含雙因子的外周神經(jīng)損傷修復(fù)膠原材料及其制備方法,發(fā)明,2015,第1作者,專利號:ZL 201410234129.9
(27) Activated collagen scaffold materials and their special fused active restoration factors.,發(fā)明,2014,第1作者,專利號:14/320,191 (美國)
(28) Activated collagen scaffold materials and their special fused active restoration factors,發(fā)明,2014,第1作者,專利號:14/320,105 (美國)
(29) 一種修飾組織工程支架的方法,發(fā)明,2015,第2作者,專利號:ZL 201210509347.X
(30) 一種用于修復(fù)脊髓損傷的圓柱體支架及其應(yīng)用方法,發(fā)明,2015,第2作者,專利號:ZL 201310045578.4
(31) 一種在組織工程支架上定量裝載生長因子的方法及其應(yīng)用,發(fā)明,2014,第2作者,專利號:ZL 201210508762.3
(32) 一種引導(dǎo)外周神經(jīng)再生的功能生物材料及其制備方法,發(fā)明,2014,第1作者,專利號:201410553525.8
(33) 一種有序膠原材料及其制備方法與應(yīng)用,發(fā)明,2014,第1作者,專利號:201410389082.3
發(fā)表論文
(1) Functionalized Collagen Scaffold Neutralizing the Myelin-Inhibitory Molecules Promoted Neurites Outgrowth in Vitro and Facilitated Spinal Cord.,ACS Appl Mater Interfaces,2015,通訊作者
(2) Modified VEGF targets the ischemic myocardium and promotes functional recovery after myocardial infarction.,J Control Release,2015,通訊作者
(3) Enhanced proliferation and osteogenic differentiation of mesenchymal stem cells on graphene oxide-incorporated electrospun poly (lactic-co-glycolic acid) nanofibrous mats.,ACS Appl Mater Interfaces,2015,通訊作者
(4) Urethral tissue regeneration using collagen scaffold modified with collagen binding VEGF in a beagle model.,Biomaterials,2015,通訊作者
(5) Electrospun Collagen Fibers with Spatial Patterning of SDF1α for the Guidance of Neural Stem Cells.,Adv Healthc Mater.,2015,通訊作者
(6) Directed osteogenic differentiation of mesenchymal stem cell in three-dimensional biodegradable methylcellulose-based scaffolds.,Colloids and Surfaces B: Biointerfaces,2015,通訊作者
(7) The collagen scaffold with collagen binding BDNFenhances functional recovery by facilitating peripheral nerve infiltrating and ingrowth in canine complete spinal cord transaction.,Spinal Cord.,2015,通訊作者
(8) Nerve regeneration and functional recovery by collagen-binding BDNF in an intracerebral hemorrhage model.,Tissue Eng Part A,2015,通訊作者
(9) Regeneration of uterine horns in rats using collagen scaffolds loaded with human embryonic stem cell-derived endometrium-like cells. ,Tissue Eng Part A ,2015,通訊作者
(10) Paracrine factors from mesenchymal stem cells attenuate epithelial injury and lung fibrosis.,Mol Med Rep.,2015,通訊作者
(11) Repair of Extrahepatic Bile Duct Defect Using a Collagen Patch in a Swine Model. ,Artif Organs,2015,通訊作者
(12) Collagen scaffolds combined with collagen-binding ciliary neurotrophic factor facilitate facial nerve repair in mini-pigs.,J Biomed Mater Res A,2015,通訊作者
(13) A collagen-binding EGFR single-chain Fv antibody fragment for the targeted cancer therapy.,J Control Release,2015,通訊作者
(14) The linear-ordered collagen scaffold-BDNF complex significantly promotes functional recovery after completely transected spinal cord injury in canine.,Biomaterials,2015,通訊作者
(15) Transplantation of hBMSCs loaded on collagen scaffolds for the regeneration of canine tissue-engineered urethras.,J Genet Genome Res.,2015,通訊作者
(16) Keep warm and get success: The role of postischemic temperature in the mouse middle cerebral artery occlusion model, Brain Res Bull.,2014,通訊作者
(17) The miR-7 identified from collagen biomaterial based 3-D cultured cells regulates neural stem cell differentiation.,Stem Cells Dev.,2014,通訊作者
(18) Linear ordered collagen scaffolds loaded with collagen-binding basic fibroblast growth factor facilitate recovery of sciatic nerve injury in rats.,Tissue Eng Part A,2014,通訊作者
(19) Promotion of neuronal differentiation of neural progenitor cells by using EGFR antibody functionalized collagen scaffolds for spinal cord injury repair.,Biomaterials,2014,通訊作者
(20) Nerve regeneration and functional recovery by collagen-binding BDNF in an intracerebral hemorrhage model. ,Tissue Eng Part A.,2014,通訊作者
(21) Collagen scaffolds modified with CNTF and bFGF promote facial nerve regeneration in minipigs.,Biomaterials,2014,通訊作者
(22) The importance of three-dimensional scaffold structure on stemness maintenance of mouse embryonic stem cells. ,Biomaterials,2014,通訊作者
(23) Collagen scaffolds combined with collagen-binding ciliary neurotrophic factor facilitate facial nerve repair in mini-pigs.,J Biomed Mater Res A,2014,通訊作者
(24) Repair of Extrahepatic Bile Duct Defect Using a Collagen Patch in a Swine Model.,Artif Organs,2014,通訊作者
(25) Accelerated postero-lateral spinal fusion by collagen scaffolds modified with engineered collagen-binding human bone morphogenetic protein-2 in rats. ,PLoS One,2014,通訊作者
(26) The inhibition effects of insulin on BMP2-induced muscle heterotopic ossification. ,Biomaterials,2014,通訊作者
(27) Use of natural neural scaffolds consisting of engineered vascular endothelial growth factor immobilized on ordered collagen fibers filled in a collagen tube for peripheral nerve regeneration in rats.,Int J Mol Sci.,2014,通訊作者
(28) Collagen scaffolds modified with collagen-binding bFGF promotes the neural regeneration in a rat hemisected spinal cord injury model.,Sci China Life Sci.,2014,通訊作者
(29) Regulation of human mesenchymal stem cells differentiation into chondrocytes in extracellular matrix-based hydrogel scaffolds.,Colloids and Surfaces B: Biointerfaces,2014,通訊作者
(30) Accelerating proliferation of neural stem/progenitor cells in collagen sponges immobilized with engineered basic fibroblast growth factor for nervous system tissue engineering., Biomacromolecules,2014,通訊作者
(31) In vitro assessment of the dual-targeting behavior of a peptide-based magnetic resonance imaging contrast agent.,Int J Mol Med.,2014,通訊作者
(32) The invitro and invivo toxicity of graphene quantum dots. Biomaterials.,Biomaterials,2014,通訊作者
(33) Transplantation of bone marrow mesenchymal stem cells on collagen scaffolds for the functional regeneration of injured rat uterus.,Biomaterials,2014,通訊作者
(34) The interplay of T1- and T2-relaxation on T1-weighted MRI of hMSCs induced by Gd-DOTA-peptides.,Biomaterials,2014,通訊作者
(35) Maintenance of the self-renewal properties of neural progenitor cells cultured in three-dimensional collagen scaffolds by the REDD1-mTOR signal pathway.,Biomaterials,2013,通訊作者
(36) Three-dimensional culture may promote cell reprogramming.,Organogenesis,2013,通訊作者
(37) Transplantation of human mesenchymal stem cells loaded on collagen scaffolds for the treatment of traumatic brain injury in rats.,Biomaterials,2013,通訊作者
(38) Direct conversion of fibroblasts into neural progenitor-like cells by forced growth into 3D spheres on low attachment surfaces.,Biomaterials,2013,通訊作者
(39) Promotion of neuronal differentiation of neural progenitor cells by using EGFR antibody functionalized collagen scaffolds for spinal cord injury repair.,Biomaterials,2013,通訊作者
(40) Promotion of diabetic wound healing by collagen scaffold with collagen-binding vascular endothelial growth factor in diabetic rat model.,J Tissue Eng Regen Med.,2013,通訊作者
(41) Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells.,Sci. Rep.,2013,通訊作者
(42) Magnetic resonance imaging of Fe3O4@SiO2-labeled human mesenchymal stem cells in mice at 11.7 T.,Biomaterials,2013,通訊作者
(43) Regulation of human mesenchymal stem cells differentiation into chondrocytes in extracellular matrix-based hydrogel scaffolds., Colloids and Surfaces B: Biointerfaces,2013,通訊作者
(44) Effect of collagen scaffold with adipose-derived stromal vascular fraction cells on diabetic wound healing: A study in a diabetic porcine model.,Tissue Engineering and Regenerative Medicine,2013,通訊作者
(45) Induction of rat facial nerve regeneration by functional collagen scaffolds.,Biomatierials,2013,通訊作者
(46) Single-molecule level binding force between collagen and collagen binding domain-growth factor conjugates.,Biomaterials,2013,通訊作者
(47) The effect of forced growth of cells into 3D spheres using low attachment surfaces on the acquisition of stemness properties.,Biomaterials,2013,通訊作者
(48) Assembled 3D cell niches in chitosan hydrogel network to mimic extracellular matrix.,Colloids and Surfaces A: Physicochem. Eng. Aspects,2013,通訊作者
(49) Evaluation of abioactivebone-inducingmaterialconsistingofcollagenscaffolds andcollagen-binding BMP2.,J Biomed Mater Res A,2013,通訊作者
(50) One-step self-assembly of ZnPc/NaGdF4:Yb,Er nanoclusters for simultaneous fluorescence imaging and photodynamic effects on cancer cells.,Journal of Materials Chemistry B,2013,通訊作者
(51) Controllable synthesis of monodispersed silver nanoparticles as standards for quantitative assessment of their cytotoxicity.,Biomaterials. 33(6):1714-21.,2012,通訊作者
(52) The enhancement of cancer stem cell properties of MCF-7 cells in 3D collagen scaffolds for modeling of cancer and anti-cancer drugs.,Biomaterials. 33(5):1437-44,2012,通訊作者
(53) The Novel Function of OCT4B Isoform-265 in Genotoxic Stress.,Stem Cells. 30(4):665-72,2012,通訊作者
(54) Neuronal regeneration and protection by collagen-binding BDNF in the rat middle cerebral artery occlusion model.,Biomaterials. 33(5):1386-95,2012,通訊作者
(55) Extrahepatic bile duct regeneration in pigs using collagen scaffolds loaded with human collagen-binding bFGF. ,Biomaterials,2012,通訊作者
(56) MiR-125b orchestrates cell proliferation, differentiation and migration in neural stem/progenitor cells by targeting Nestin.,BMC Neurosci.,2012,通訊作者
(57) The effect of collagen-binding vascular endothelial growth factor on the remodeling of scarred rat uterus following full-thickness injury.,Biomaterials. 33(6):1801-7.,2012,通訊作者
(58) The use of laminin modified linear ordered collagen scaffolds loaded with laminin-binding ciliary neurotrophic factor for sciatic nerve regeneration in rats. ,Biomaterials. 32(16):3939-48,2011,通訊作者
(59) Improved cellularization and angiogenesis using collagen scaffolds chemically conjugated with vascular endothelial growth factor. ,Acta Biomaterialia. 7(3):1084-93,2011,通訊作者
(60) Regeneration of full-thickness abdominal wall defects in rats using collagen scaffolds loaded with collagen-binding basic fibroblast growth factor., Biomaterials. 32(3): 753-9.,2011,通訊作者
(61) Stem-cell-capturing collagen scaffold promotes cardiac tissue regeneration., Biomaterials. 32(10):2508-15.,2011,通訊作者
(62) The promotion of neurological recovery in an intracerebral hemorrhage model using fibrin-binding brain derived neurotrophic factor. ,Biomaterials. 32(12):3244-52,2011,通訊作者
(63) Regeneration of uterine horns in rats by collagen scaffolds loaded with collagen-binding human basic fibroblast growth factor. ,Biomaterials,2011,通訊作者
(64) A Myocardial Patch Made of Collagen Membranes Loaded with Collagen-Binding Human Vascular Endothelial Growth Factor Accelerates Healing of the Injured Rabbit Heart.,Tissue Engineering Part A. 17(21-22):2739-47.,2011,通訊作者
(65) Neural regrowth induced by PLGA nerve conduits and neurotrophin-3 in rats with complete spinal cord transaction. ,J Biomed Mater Res B Appl Biomater. 97(2):271-7.,2011,通訊作者
(66) The osteogenic effect of bone morphogenetic protein-2 on the collagen scaffold conjugated with antibodies.,J Controlled Release. 141(1):30-7.,2010,通訊作者
(67) Collagen scaffolds loaded with collagen-binding NGF-beta accelerate ulcer healing., J Biomed Mater Res A. 92(3):887-95.,2010,通訊作者
(68) Differential effects of recombinant fusion proteins TAT-OCT4 and TAT-NANOG on adult human fibroblasts.,F(xiàn)rontiers in Biology,2010,通訊作者
(69) Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells., Stem Cells Dev. 19(1):53-60,2010,通訊作者
(70) Loading of VEGF to the heparin cross-linked demineralized bone matrix improves vascularization of the scaffold. ,J Mater Sci Mater Med. 21(1):309-17,2010,通訊作者
(71) Mapping of the minimal internal ribosome entry site element in the human embryonic stem cell gene OCT4B mRNA., Biochem Biophys Res Commun. 394(3):750-4.,2010,通訊作者
(72) The novel OCT4 spliced variant OCT4B1 can generate three protein isoforms by alternative splicing into OCT4B., J Genet Genomics. 37(7):461-5,2010,通訊作者
(73) Isoforms of OCT4 contribute to the confusing diversity in stem cell biology,Stem Cells. 28(5):885-93.,2010,通訊作者
(74) Bladder regeneration by collagen scaffolds with collagen binding human basic fibroblast growth factor. ,J Urol. 183(6):2432-9.,2010,通訊作者
(75) Linear ordered collagen scaffolds loaded with collagen-binding neurotrophin-3 promotes axonal regeneration and partial functional recovery after complete spinal cord transaction. ,J Neurotrauma. 27(9):1671-83.,2010,通訊作者
(76) Acceleration of diabetic wound healing by collagen-binding vascular endothelial growth factor in diabetic rat model. ,Diabetes Research and Clinical Practice. 90(1):66-72.,2010,通訊作者
(77) The promotion of neurological recovery in the rat spinal cord crushed injury model by collagen-binding BDNF., Biomaterials. 31(33):8634-41,2010,通訊作者
(78) The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an EGFR neutralizing antibody. ,Biomaterials. 31(35):9212-20,2010,通訊作者
(79) The human pluripotency gene NANOG/NANOGP8 is expressed in gastric cancer and associated with tumor development., Oncology Letters. 1(3): 457-63,2010,通訊作者
(80) Stem cell research is coming of age in China.,J Genet Genomics. 37(7):413.,2010,第1作者
(81) Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction., Circulation. 119(13):1776-84.,2009,通訊作者
(82) Direct chemical cross-linking of platelet-derived growth factor-BB to the demineralized bone matrix improves cellularization and vascularization. ,Biomacromolecules. 10(12):3193-8.,2009,通訊作者
科研項目
(1) 面向干細胞微環(huán)境構(gòu)建的低溫細胞3D重建系統(tǒng),主持,院級級,2014-01--2015-12
(2) 基于快速成型技術(shù)的新型神經(jīng)組織工程支架材料研發(fā),參與,國家級,2013-06--2016-06
(3) 功能生物材料與組織器官工程產(chǎn)品研究,參與,部委級,2012-01--2015-12
(4) 三維培養(yǎng)干細胞自我更新與定向分化的調(diào)控網(wǎng)絡(luò),主持,國家級,2011-01--2015-12
(5) 膠原結(jié)合能力的血管內(nèi)皮生長因子對豬心肌損傷的治療作用及安全性評價,主持,部委級,2011-01--2013-12
(6) 人工組織器官構(gòu)建,主持,院級級,2011-01--2015-12
(7) 神經(jīng)再生環(huán)境的構(gòu)建,主持,部委級,2010-01--2013-12
(8) OCT4 異構(gòu)體的表達、功能和調(diào)節(jié)機制的研究,主持,部委級,2010-01--2012-12
(9) 骨損傷定向修復(fù)活性骨材料的研制,主持,院級級,2009-01--2011-12 以上老師的信息來源于學(xué)校網(wǎng)站,如有更新或錯誤,請聯(lián)系我們進行更新或刪除,聯(lián)系方式
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